Felis ISSN 2398-2950
Contributor(s): Kathleen P Freeman, Elisa Mazzaferro
- A presenting sign of lower than normal serum protein levels.
- Cause: secondary to another primary disease process causing protein loss or decreased protein synthesis/availability:
- Protein-losing enteropathy Protein-losing enteropathy.
- Protein-losing nephropathy.
- Impaired protein synthesis/absorption.
- Protein deficiency/loss.
- Signs: signs of primary disease process until chronic when generalized peripheral edema, pleural/abdominal effusion, weight loss, muscle wasting, cachexia.
- Treatment: same as primary disease process.
- Prognosis: same as primary disease process.
- Same as primary disease process.
- Primary disease process causes increased loss, reduced uptake or decreased availability of protein → reduced serum protein levels.
- Decreased plasma protein → hypoalbuminemia → decreased plasma osmotic pressure → fluid transudation from capillaries → generalized peripheral edema and pleural/abdominal effusions Effusion: overview → pleural effusion/ascites → clinical signs.
- Chronic condition before signs seen.
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- Recent references from PubMed and VetMedResource.
- Moore L E (1998) Fluid therapy in the hypoproteinemic patient. Vet Clin North Am Small Anim Pract 28 (3), 709-715 PubMed.
Other sources of information
- Ettinger S J, Feldman E C, Cote E (eds) (2017) Textbook of Veterinary Internal Medicine. 8th edn. St Louis: Elsevier.
- Stockham S L, Scott M A (2002) Fundamentals of Veterinary Clinical Pathology. Iowa: Iowa State Press.