ISSN 2398-2950      

Hypoproteinemia

ffelis

Synonym(s): Hypoalbuminemia


Introduction

  • A presenting sign of lower than normal serum protein levels.
  • Cause: secondary to another primary disease process causing protein loss or decreased protein synthesis/availability:
    • Protein-losing enteropathy Protein-losing enteropathy.
    • Protein-losing nephropathy.
    • Impaired protein synthesis/absorption.
    • Protein deficiency/loss.
  • Signs: signs of primary disease process until chronic when generalized peripheral edema, pleural/abdominal effusion, weight loss, muscle wasting, cachexia.
  • Treatment: same as primary disease process.
  • Prognosis: same as primary disease process.

Pathogenesis

Etiology

  • Same as primary disease process.

Pathophysiology

  • Primary disease process causes increased loss, reduced uptake or decreased availability of protein  →  reduced serum protein levels.
  • Decreased plasma protein  →  hypoalbuminemia  →  decreased plasma osmotic pressure  →  fluid transudation from capillaries  →  generalized peripheral edema and pleural/abdominal effusions  Effusion: overview →  pleural effusion/ascites  →  clinical signs.

Timecourse

  • Chronic condition before signs seen.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Moore L E (1998) Fluid therapy in the hypoproteinemic patient. Vet Clin North Am Small Anim Pract 28 (3), 709-715 PubMed.

Other sources of information

  • Ettinger S J, Feldman E C, Cote E (eds) (2017) Textbook of Veterinary Internal Medicine. 8th edn. St Louis: Elsevier.
  • Stockham S L, Scott M A (2002) Fundamentals of Veterinary Clinical Pathology. Iowa: Iowa State Press.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!