ISSN 2398-2950      

Congenital panhypopituitarism

ffelis

Synonym(s): Pituitary dwarfism Congenital hyposomatotropism


Introduction

  • Rare congenital disease, mainly anecdotally reported cases.
  • Cause: pituitary gland replaced by cystic dilation of Rathke's cleft.
  • Signs: depend on extent of pituitary involvement; appear normal at birth; retarded growth noticed around weaning, with one or more affected in a litter   →   proportionate dwarfs.
  • Diagnosis: radiology, hormone assays.
  • Treatment: growth hormone therapy.
  • Prognosis: dwarfism usually permanent, mean age 4 years despite treatment.

Pathogenesis

Pathophysiology

  • 1° failure of differentiation of adenohypophyseal cells into normal tropic hormone secreting cells.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

Other sources of information

  • Feldman E C and Nelson R W (1996) Disorders of growth hormone. In: Canine and Feline Endocrinology and Reproduction 2nd Ed.WB Saunders, Philadelphia. pp 38-66.

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