Felis ISSN 2398-2950

Cleft lip and palate

Contributor(s): David Crossley, Elisa Mazzaferro

Introduction

  • Congenital defect or traumatic separation of primary (cleft lip) and/or secondary (cleft palate) palate.
  • Cause: stress, genetic, environmental, drug induced or trauma (adult).
  • Signs: rhinitis +/- pneumonia.
  • Treatment: surgical closure.
  • Prognosis: reasonable, variable surgical success rates, fatal if not able to suckle.

Pathogenesis

Etiology

  • Multiple genetic factors.
  • Stress, teratogens in first three weeks of gestation, eg griseofulvin Griseofulvin, corticosteroids Prednisolone, vitamin A Vitamin A deficiency/toxicity/excess.

Pathophysiology

  • Failure of palate to fuse during development   →   communication between oral and nasal cavities   →   failure to suckle due to inability to develop negative pressure required   →   also passage of food to nasal cavity   →   rhinitis and possible aspiration pneumonia.

Timecourse

  • Days/weeks/months/years.

Diagnosis

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Prevention

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers


ADDED