ISSN 2398-2950      

Chronic lymphoid leukemia

ffelis
Contributor(s):

Irene Rochlitz

Synonym(s): CLL


Introduction

  • Rare disease in cat much less common than acute lymphoid leukemia Acute lymphoblastic leukemia.
  • Cause: neoplastic transformation and proliferation of late precursor lymphoid cells.
  • Signs: slow progression and mild clinical signs. May be incidental finding.
  • Diagnosis: predominance of mature lymphoid cells in bone marrow and marked lymphocytosis.
  • Treatment: supportive, specific cytotoxic agents.
  • Prognosis: reasonable.
Print off the owner factsheet on Feline leukaemia to give to your client.

Pathogenesis

Etiology

Pathophysiology

  • Replacement of normal bone marrow tissue with neoplastic cells   →   myelosuppression   →   anemia, thrombocytopenia, granulocytopenia   →   secondary infections common.
  • Transformation of late precursor cells   →   proliferation of mature, differentiated cells   →  chronic leukemia  Leukemia  →   less severe cytopenia.
  • Excessive numbers of circulating cells/hyperproteinemia Hypoproteinemia  →   hyperviscosity   →   decreased oxygen transport to capillary beds   →   microthrombi of tumor cells.
  • Production of humoral factors   →   stimulation of osteoclasts   →   hypercalcemia Hypercalcemia: overview of malignancy   →   polyuria/polydypsia   →   renal failure Kidney: chronic kidney disease.

Timecourse

  • Months to years.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Darbès J, Majzoub M, Breuer W et al (1998) Large granular lymphocyte leukemia/lymphoma in six cats. Vet Pathol 35 (5), 370-379 PubMed.
  • Schick R O, Murphy C F, Goldschmidt M H (1993) Cutaneous lymphosarcoma and leukemia in a cat. JAVMA 203 (8), 1155-1158 PubMed.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!