ISSN 2398-2950      

Chondrosarcoma

ffelis

Synonym(s): CSA


Introduction

  • Primary bone tumors are rare in the cat. Chondrosarcoma is less common than osteosarcoma Osteosarcoma, and accounts for <10% of primary bone tumors.
  • Few cases are reported, so generalization is difficult.
  • Most commonly affect axial skeleton, ie flat bones, but long bones affected also.
  • A primary tumor of cartilage, but can arise secondarily within benign cartilaginous masses.
  • Signs: Painful or non-painful firm swellings, lameness if limb bone affected.
  • Diagnosis: radiography, histopathology.
  • Treatment: limb amputation/tumor resection.
  • Prognosis: Less aggressive than osteosarcomas, so early diagnosis and treatment may yield good prognosis.

Pathogenesis

Etiology

  • A spontaneous malignant neoplasm with unknown etiology.

Pathophysiology

  • Malignant tumor arising from cartilage.
  • May arise secondarily within a benign cartilaginous mass, such as multilobular chondroma.
  • No known predisposing factors.
  • Scapula reported as a common site on cats, but few reports in total.
  • Proliferating malignant cartilage cells with secretion of cartilaginous matrix, leads to local swelling and possible development of metastatic potential.
  • Metastasis to lungs reported in the cat, but documented cases are few.
  • Grow more slowly, with a longer clinical course and later haematogenous metastasis, and less often, compared with osteosarcoma

Timecourse

  • With high-grade malignancy, metastasis may occur within weeks.
  • Some clinical cases have 1-6 months of clinical signs reported, however.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Levy M S, Mauldin G, Kapatkin A S et al (1997) Nonlymphoid vertebral canal tumors in cats: 11 cases (1987-1995). J Am Vet Med Assoc 210 (5), 663-664 PubMed.
  • Davidson J R (1995) Canine and feline chondrosarcoma. Comp Cont Educ 17 (9), 1109-1114 VetMedResource.
  • Turrel J M & Pool R R (1982) Primary bone tumors in the cat: A retrospective survey of 15 cats and a literature review. Vet Radiol 23 (4), 152-166 Wiley Online Library.

Other sources of information

  • Thompson K G & Pool R R (2002). Chapter 5. Tumors of bones. pp 245-317. In: Meuten D J (Ed.) Tumors in Domestic Animals. 4th Edn. Iowa State Press.
  • Carpenter J L, Andrews K L & Holzworth J (1987) Chapter 11. Tumors and tumor-like lesions. In: Holzworth J (Ed) Diseases of the cat  - Medicine and surgery. pp 406-596. WB Saunders.

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