ISSN 2398-2950      

Chondrodysplasia

ffelis
Contributor(s):

Kim Willoughby


Introduction

  • Literally means abnormal growth of cartilage and results in disproportionate dwarfism.
  • Cause: rare, genetic cartilage abnormality.
  • Signs: limb shortening and flared metaphyses, depressed nasal bridge and shortened maxilla   →   crowding of teeth Crowding of teeth.
  • Diagnosis: clinical signs.
  • Treatment: none.
  • Prognosis: poor.

Pathogenesis

Pathophysiology

  • Abnormal interstitial growth of physeal cartilage   →   generalized shortening of the bones which develop by endochondral ossification:
    • Limbs.
    • Ribs.
    • Vertebral column.
  • Early growth arrest of some bones that make up the cranium   →   enlarged dome-shaped skull due to continued brain growth.
  • Hypoplasia of base of cranium, ethmoids and turbinates   →   flattened face   →   normal sized tongue then protrudes beyond jaw.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Latimer K S, Rowland G N and Mahaffey M B (1988) Homozygous Pelger-Huë​t anomaly and chondrodysplasia in a stillborn kitten. Vet Pathol 25 (4), 325-328 PubMed.
  • Hegreberg G A, Norby D E and Hamilton M J (1974) Lysosomal enzyme changes in an inherited dwarfism of cats. Fed Proc 33 (No. 3 Part I), 598-561 VetMedResource.

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