Felis ISSN 2398-2950

Birman neutrophil granulation anomaly

Contributor(s): Severine Tasker

Introduction

  • Cause: rare hereditary trait in Birman cats resulting in altered neutrophil cytoplasm granularity.
  • Signs: increased granularity of the cytoplasm of abnormal neutrophils that resemble immature cells. Neutrophil function is unaffected.
  • Diagnosis: cytology.
  • Treatment: none required.
  • Prognosis: good.

Pathogenesis

Etiology

  • An autosomal recessive hereditary abnormality resulting in increased granularity of the cytoplasm of abnormal neutrophils that resemble the cytoplasm of immature cells. Granules may appear red/azurophilic (eosinophilic) on Wright-Giemsa staining. Neutrophil function (eg phagocytosis, oxidative metabolism, bacteriocidal activity) is unaffected.

Pathophysiology

  • Affected cats have fine eosinophilic granules (Romanowsky or Wright-Giemsa stains) in the cytoplasm of their neutrophils due to an alteration in the content of lysosomal granules with increased affinity for acidic dyes.

Timecourse

  • Unknown but likely present from birth.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Thompson J C (2009) Unusual granulation of neutrophils from Siamese cats and possible link with granulation in Birman cats. NZ Vet J 57 (1), 70 ResearchGate
  • Segev G, Klement E, Aroch I (2006) Toxic Neutrophils in Cats: Clinical and Clinopathologic Features, and Disease Prevalence and Outcome - A Retrospective Case Control Study. J Vet Intern Med (20) (1), 20-31 PubMed.
  • Hirsch V M, Cunningham T A (1984) Hereditary anomaly of neutrophil granulation in Birman cats. Am J Vet Res 45 (10), 2170-2174 PubMed.

Other sources of information

  • Hostetter S J (2012) Neutrophil Function in Small Animals. Vet Clin Small Animal 42 (1), 151-171 PubMed.
  • Little S (2012) The Cat Clinical Medicine and Management. Chapter 25, pp 678.


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