Exotis ISSN 2398-2985

Reptiles

Ticarcillin

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Ticarcillin.

Class of drug

  • Carboxypenicillin antibiotic.
  • Semi-synthetic penicillin.

Description

Chemical name

  • (2S,5R,6R)-6-{[(2R)-2-carboxy-2-(3-thienyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.

Molecular formula

  • C15H16N2O6S2.

Molecular weight

  • 384.43.

Physical properties

  • White to pale yellow, hygroscopic powder of lyophilized cake.
  • More than 600 mg is soluble in 1 mL of water.

Storage requirements

  • Injectable powder should be stored at temperatures less than 30°C/86°F.
  • After reconstitution it is stable for 48-72 h in the fridge. The reconstituted solution should not be left at room temperature.
  • Frozen solutions (-20°C/-4°F) are stable at least for 30 days.

Uses

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Indications

  • Indicated for serious or life-threatening bacterial infections, particularly those involving Pseudomonas aeruginosa.
  • Always used when culture and sensitivity do not provide more available options.
  • Relatively expensive antibiotic

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Aminoglycosides
  • Do not mix gentamicin with ticarcillin because there may be mutual inactivation.
  • Ticarcillin + clavulanic acid + amikacin appears to be safer or even synergistic in vivo (but should not be mixed in the same syringe).

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Manire C A, Hunter R P, Koch D E et al (2005) Pharmacokinetics of ticarcillin in the loggerhead sea turtle (Caretta caretta) after single intravenous and intramuscular injections. J Zoo Wildl Med 36 (1), 44-53 PubMed.

Other sources of information

  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • McArthur S, Wilkinson R & Meyer J (2004) Medicine and Surgery of Tortoises and Turtles. Wiley Blackwell, UK. pp 579.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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