Exotis ISSN 2398-2985

Reptiles

Silver sulfadiazine

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Silver sulfadiazine.

Class of drug

  • Topical anti-bacterial and anti-fungal agent.

Description

Chemical name

  • Silver [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide.

Molecular formula

  • C10H9AgN4O2S

Molecular weight

  • 357.14.

Physical properties

  • Poorly soluble in water.
  • Soft, white, water-miscible cream.

Storage requirements

  • Do not store above 25°C/77°F.
  • Store in the original container in order to protect from light.

Uses

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Indications

  • A topical anti-bacterial and anti-fungal drug which is particularly active against Gram-negative organisms such as Pseudomonas aeruginosa.
  • Used in the management of burns, other skin wounds, infectious stomatitis, etc.
  • Up to 10% may be absorbed depending on the size of the area to be treated. Penetration through intact skin may be negligible.

Administration

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Pharmacokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Cusack L M, Mayer J, Cutler D C et al (2018) Gross and histologic evaluation of effects of photobiomodulation, silver sulfadiazine, and a topical antimicrobial product on experimentally induced full-thickness skin wounds in green iguanas (Iguana iguana). Am J Vet Res 79 (4), 465-473 PubMed.

Other sources of information

  • Mader D R (2006) Ed Reptile Medicine and Surgery. Saunders Elsevier, USA. pp 1242.
  • McArthur S, Wilkinson R & Meyer J (2004) Medicine and Surgery of Tortoises and Turtles. Wiley Blackwell, UK. pp 579.
  • Girling S J & Raiti P (2004) BSAVA Manual of Reptiles. BSAVA, UK. pp 383.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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