Exotis ISSN 2398-2985

Reptiles

Sevoflurane

Synonym(s): Sevo, Fluoromethyl, SevoFlo

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Sevoflurane.

Class of drug

  • Halogenated inhalation anesthetic drug.

Description

Chemical name

  • Fluoromethyl 2,2,2-trifluoro-l-(trifluoromethyl)ethyl ether.

Molecular formula

  • C4H3F7O.

Molecular weight

  • 200.05.

Physical properties

  • Clear, colorless non-pungent volatile liquid (isopropyl ether).
  • Boiling point 58.5°C/137.3°F, saturated vapor.
  • Blood-gas partition coefficient of 0.7.
  • Pressure at 20°C/68°F of 160 mmHg.

Storage requirements

  • Store in manufacturers' amber colored bottles.
  • Store at room temperature (15-30°C/59-86°F).

Uses

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Indications

  • Safe and effective general anesthesia in reptiles (both induction and maintenance).
  • Currently more expensive than isoflurane Isoflurane.
  • As a general rule, no significant differences have been observed between sevoflurane and isoflurane in reptiles. Some studies have indicated some differences (mainly faster recovery times); while those differences may be statistically significant, it is not clear if they are also clinically significant (more subjective to assess), particularly considering the significantly higher price of sevoflurane.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Prolongs the effects of neuromuscular blocking agents.
  • Interacts with desiccated carbon dioxide (soda lime and barium hydroxide lime) absorbents to produce carbon monoxide and Compound A.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell, UK. pp 1296.
  • McArthur S, Wilkinson R & Meyer J (2004) Medicine and Surgery of Tortoises and Turtles. Blackwell Publishing, UK. pp 579.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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