Exotis ISSN 2398-2985

Reptiles

Propofol

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Propofol

Class of drug

  • Ultra short-acting phenolic intravenous anesthetic.

Description

Chemical name

  • 2,6-diisopropylphenol.

Molecular formula

  • C12H18O.

Molecular weight

  • 178.27.

Physical properties

  • The commercially available injection is a white emulsion that also contains soybean oil, glycerol and egg lecithin.
  • PropoClear is available in some countries; it is not white and contains other excipients.

Storage requirements

  • Store at 4-22°C/39.2-71.6°F.
  • Do not refrigerate or freeze.
  • Protect from light.
  • Shake well before use.
  • Do not use if the emulsion has separated.
  • Once a vial is open, the manufacturer recommends discarding the remaining product after 6 h, even if sterile handling conditions are used. When benzyl alcohol is added to the emulsion (Propoflo 28, Propoflo Plus) the shelf-life (after opening) is extended to 28 days. PropoClear has also a shelf-life after opening of 28 days.

Uses

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Indications

  • Anesthesia indicated for short procedures or for induction prior to inhalation anesthesia.
  • Maintenance of general anesthesia with propofol is not recommended as better alternatives are available.
  • Anesthetic, hypnotic, muscle relaxant.
  • Sedative at low doses.

Administration

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Pharmacokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Mader D R (2006) Ed Reptile Medicine and Surgery. Saunders Elsevier, USA. pp 1242.
  • Girling S J & Raiti P (2004) BSAVA Manual of Reptiles. BSAVA, UK. pp 383.
  • McArthur S, Wilkinson R & Meyer J (2004) Medicine and Surgery of Tortoises and Turtles. Blackwell Publishing, UK. pp 579.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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