Exotis ISSN 2398-2985

Reptiles

Piperacillin

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Piperacillin sodium.
  • Also available with a beta-lactamase inhibitor (tazobactam).

Class of drug

  • Extended spectrum beta-lactam antibiotic of the ureidopenicillin class.

Description

Chemical name

  • (2S,5R,6R)-6-{[(2R)-2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)amino]-2-phenyl-acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.

Molecular formula

  • C23H27N5O7S.

Molecular weight

  • 517.55.

Physical properties

  • White or almost white, hygroscopic powder.
  • Freely soluble in water or alcohol.

Storage requirements

  •  Vials should be stored at controlled room temperature (20-25°C/68-77°F).
  • Once reconstituted, vials should be used within 4 hours of initial puncture.
  • The manufacturer recommends not freezing reconstituted vials; however, studies have shown that both piperacillin and piperacillin/tazobactam keep more than 90% efficacy when refrigerated at 4°C/39.2°F for 35 days or when frozen at -20°C/-4°F for 3 months.

Uses

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Indications

  • Reserved for life-threatening infections when indicated by culture and sensitivity.
  • Not commonly used as a first line of action. In addition, its use may be restricted to human hospitals in some countries, which makes veterinary use more challenging.
  • It can be combined with amikacin Amikacin to increase spectrum of activity.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Variable synergism/inactivation with aminoglycosides.
Non-depolarizing muscle relaxants
  • Piperacillin enhances effects
Probencid
  • Reduces excretion of piperacillin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Hilf M, Swanson D, Wagner R et al (1991) Pharmacokinetics of piperacillin in blood pythons (Python curtus) and in vitro evaluation of efficacy against aerobic gram-negative bacteria. J Zoo Wildl Med 22 (2), 199-203 VetMedResource.

Other sources of information

  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Carpenter J W & Marion C J (2013) Exotic Animal Formulary. 4th edn. Saunders, Philadelphia.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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