Exotis ISSN 2398-2985

Reptiles

Oxytocin

Synonym(s): Pitocin, Syntocinon, Oxytocin S

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Oxytocin.

Class of drug

  • Hormone.

Description

Chemical name

  • 1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide.

Molecular formula

  • C43H66N12O12S2.

Molecular weight

  • 1007.19.

Physical properties

  • White powder, soluble in water.
  • One unit is equivalent of approximately 2-2.2 µg of pure hormone.
  • The commercially available preparations are highly purified and have virtually no antidiuretic or vasopressor activity.

Storage requirements

  • Room temperature.
  • Avoid freezing.

Uses

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Indications

  • Induction of oviposition when uterine inertia is present (as long as no obstruction is present).
  • Most commonly used in chelonians.
  • Prostaglandins may be more effective than oxytocin, particularly in lizards and snakes.
  • It has also been used recently to induce oviposition in healthy females, particularly in field conditions or in turtle farms. This use is questionable from an ethical and medical point of view.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Sympathomimetic pressor amines
  • Severe hypertension may develop.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Di Ianni F, Parmigiani E, Pelizzone I et al (2014) Comparison between intramuscular and intravenous administration of oxytocin in captive-bred red-eared sliders (Trachemys scripta elegans) with non-obstructive egg retention. J Exotic Pet Med 23 (1), 79-84 SciDirect.
  • Tucker J K, Thomas D L & Rose J (2007) Oxytocin dosage in turtles. Chelonian Cons Biol 6 (2), 321-324 BioOne.

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • McArthur S, Wilkinson R & Meyer J (2004) Medicine and Surgery of Tortoises and Turtles. Blackwell Publishing, UK. pp 579.
  • Mader D R (2006) Ed Reptile Medicine and Surgery. Saunders Elsevier, USA. pp 1242.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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