Exotis ISSN 2398-2985

Reptiles

Medetomidine

Synonym(s): Medetomidine HCl, Domitor, Domtor, Zalopine, Dorbene, Dormilan, Medetor, Sedastart, Sedator, Sededorm

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Medetomidine.

Class of drug

  • Alpha-2 adrenergic agonist.

Description

Chemical name

  • (RS)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole.

Molecular formula

  • Cl3H16N2.

Molecular weight

  • 200.28.

Physical properties

  • White or almost white crystalline substance.
  • It is soluble in water.

Storage requirements

  • Room temperature and protected from freezing.

Uses

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Indications

  • To provide sedation and analgesia Analgesia, or to increase sedation/analgesia time when used in combination with other drugs, eg propofol Propofol.
  • Good visceral analgesia.
  • Has very potent anesthetic-sparing properties when used as a premedicant.
  • It counteracts muscle rigidity associated with 'dissociative anesthesia' (ketamine).
  • It may be used in conjunction with propofol, midazolam and opioids to improve the effect of chemical restraint.
  • Cardiovascular depression limits its use in reptiles.
  • It should be combined with other anesthetics; its use alone may not be recommended.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Do not use in patients receiving sympathomimetic amines or drugs that depress the cardiovascular system, eg propofol.
  • When used for premedication, medetomidine will significantly reduce the dose of all other anesthetic agents.

with diagnostic tests

  • Causes a transient increase in blood glucose, so affects blood glucose determinations.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Hansen L L & Bertelsen M F (2013) Assessment of the effects of intramuscular administration of alfaxalone with and without medetomidine in Horsfield’s tortoises (Agrionemys horsfieldii). Vet Anaesth Analg 40 (6), E68-E75 PubMed.
  • Hernandez-Divers S J, Stahl S J & Farrell R (2009) An endoscopic method for identifying sex of hatchling Chinese box turtles and comparison of general versus local anesthesia for coelioscopy. J Am Vet Med Assoc 234 (6), 800-804 VetMedResource.

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA, UK. ISBN: 9781905319657.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.
  • Girling S J & Raiti P (2004) BSAVA Manual of Reptiles. BSAVA, UK. pp 383.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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