Exotis ISSN 2398-2985

Reptiles

Marbofloxacin

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Marbofloxacin.

Class of drug

  • Antibiotic.
  • Fluoroquinolone.

Description

Chemical name

  • 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridol(3,2,1-ij)(4,2,1)benzoxadiazin-6 carboxylic acid.

Molecular formula

  • C17H19FN4O4.

Molecular weight

  • 362.361.

Physical properties

  • Soluble in water, but solubility decreases as pH increases.

Storage requirements

  • Protected from heat, light and moisture.
  • Store at less than 30°C/86°F.

Uses

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Indications

  • Effective against mycoplasmas (eg Chlamydia, Mycoplasma) and many gram-negative organisms including Pasteurella spp, Pseudomonas aeruginosa, Klebsiella spp, Escherichia coli, Proteus spp and Salmonella spp.
  • Effective against some gram-negatives, but marbofloxacin is not indicated for infections with gram-negative bacteria unless sensitivity tests indicate so.
  • Ineffective against anaerobic infections.
  • Fluoroquinones are highly lipophilic and atain high concentrations within cells in many tissues.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Adsorbents and antacids
  • Containing cations (Mg, Al) may bind to fluoroquinolones and prevent their absorption from the GIT.
Theophylline
  • Fluoroquinolones increase plasma theophylline concentrations.
Probenecid
  • Blocks the tubular secretion of fluoroquinolones and may increase their blood level and half-life.
Cimetidine
  • It may reduce the clearance of fluoroquinolones.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Shan Q, Zheng G, Liu S et al (2015) Pharmacokinetic/pharmacodynamic relationship of marbofloxacin against Aeromonas hydrophila in Chinese soft-shelled turtles (Trionyx sinensis). J Vet Pharmacol Ther 38 (6), 537-542 PubMed.
  • Rueegg S R, Regenscheit N, Origgi F C et al (2015) Detection of Chlamydia pneumoniae in a collection of captive snakes and response to treatment with marbofloxacin. Vet J 205 (3), 424-426 PubMed.
  • Marin P, Lai O R, Laricchiuta P et al (2009) Pharmacokinetic of marbofloxacin after a single oral dose to loggerhead sea turtles (Caretta caretta). Res Vet Sci 87 (2), 284-286 PubMed.
  • Lai O R, Marin P, Laricchiuta P et al (2009) Pharmacokinetics of marbofloxacin in loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular doses. J Zoo Wildl Med 40 (3), 501-507 PubMed.

Other sources of information

  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell, USA. pp 1296.
  • Ramsey I (2014) BSVA Small Animal Formulary. 8th edn. BSAVA, UK.
  • Girling S J & Raiti P (2004) BSAVA Manual of Reptiles. BSAVA, UK. pp 383.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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