Exotis ISSN 2398-2985

Reptiles

Lactated Ringer's solution

Synonym(s): LRS, Hartmann's

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Lactated Ringer's Solution (LRS).

Class of drug

  • Isotonic electrolyte solution.

Description

Molecular formula

  • Each liter contains:
    • 6.0 g sodium chloride.
    • 0.4 g potassium chloride.
    • 0.27 g calcium chloride dehydrate.
    • 28.9 ml of molar sodium lactate.
  • Which is equivalent to:
    • 130 mmol/L sodium.
    • 109 mmol/L chloride.
    • 28 mmol/L lactate.
    • 4 mmol/L potassium.
    • 1.5 mmol/L calcium.
  • Lactated Ringer’s solution has an osmolarity of 273 mOsm/L.
  • Lactated Ringer’s solution has a caloric content of 9 Kcal/L.

Physical properties

  • Clear colorless solution.

Storage requirements

  • Store at 2-25°C/35.6-77°F (shelf-life 2 years).

Uses

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Indications

  • Reptile osmolality (measured in snakes) is 345 mOsm/L, which is higher than in mammals.
  • Therefore, LRS is not isotonic in reptiles, but hypotonic.
  • An isotonic solution for reptiles may be 1 part of 5% dextrose in 4 parts of 0.9% saline.
  • Lactated Ringer’s solution is used to replace fluids and electrolytes.
  • To treat metabolic acidosis.
  • Lactate is added to act as an alkalinizing agent.
  • However, some authors advocate that nonlactated fluid therapy should be administered to reptiles whenever possible, as sick reptiles may already accumulate a significant lactate load.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with diagnostic tests

  • Avoid collecting blood samples immediately after delivering fluid therapy.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Sanchez-MIgallon D, Mitchell M A & Acierno M (2011) Determination of plasma osmolality and agreement between measured and calculated values in captive male corn snakes (Pantherophis [Elaphe] guttatus guttatus). J Herpetol Med Surg 21 (1), 16-19 VetMedResource.

Other sources of information

  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.
  • Prezant R M & Jarchow J L (1997) Lactated Fluid Use in Reptiles: Is There a Better Solution? In: Proc 4th Annual ARAV Conference. pp 83-87.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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