Exotis ISSN 2398-2985

Reptiles

Flumazenil

Synonym(s): Flumazenilum, Flumazepil, Romazicon, Flumazen, Anexate, Lanexat, Flumage

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Flumazenil.

Class of drug

  • Selective benzodiazepine receptor antagonist.

Description

Chemical name

  • ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate.

Molecular formula

  • C15H14FN3O3.

Molecular weight

  • 303.29.

Physical properties

  • White to off-white crystalline compound, insoluble in water but soluble in acidic aqueous solutions.

Storage requirements

  • Once drawn into a syringe or mixed with solutions, discard after 24 h.

Uses

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Indications

  • Reversal of benzodiazepine effects after either therapeutic use or overdosages.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Do not use with tricyclic antidepressants.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Doss G A, Fink D M, Sladky K K et al (2017) Comparison of subcutaneous dexmedetomidine-midazolam versus alfaxalone-midazolam sedation in leopard geckos (Eublepharis macularius). Vet Anaesth Analg 44 (5), 1175-1183 PubMed.

Other sources of information

  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell, USA. pp 1296.
  • Carpenter J W & Marion C J (2013) Exotic Animal Formulary. 4th edn. Saunders, USA.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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