Exotis ISSN 2398-2985

Reptiles

Ciprofloxacin

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Ciprofloxacin.

Class of drug

  • Fluoroquinolone antibiotic.

Description

Chemical name

  • 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid.

Molecular formula

  • C17H18FN3O3.

Molecular weight

  • 331.4.

Physical properties

  • Faintly yellowish to light yellow crystalline powder.
  • Slightly soluble in water.

Storage requirements

  • Oral formulation: store at room temperature and avoid UV exposure.
  • Injectable formulation: store at room temperature, avoid UV exposure and do not freeze.

Uses

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Indications

  • Many gram-negative and gram-positive bacterial and mycoplasmal infections.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • The binding of ciprofloxacin to serum proteins is 20-40% which is not likely to be high enough to cause significant protein binding interactions with other drugs.
  • Probenecid increases serum concentrations of ciprofloxacin.
  • Concurrent administration of antacids containing magnesium hydroxide or aluminum hydroxide may reduce the bioavailability of ciprofloxacin by as much as 90%.
  • Sucralfate inhibits absorption of ciprofloxacin; separate doses of these drugs by at least 2 h.
  • Concomitant administration with tizanidine or theophylline is contraindicated.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Wimalasena S H M P, Shin G W, Hossain S et al (2017) Potential enterotoxicity and antimicrobial resistance pattern of Aeromonas species isolated from pet turtles and their environment. J Vet Med Sci 79 (5), 921-926 PubMed.

Other sources of information

  • Meredith A (2015) Ed Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK.
  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell, USA. pp 1296.
  • Carpenter J W & Marion C J (2013) Exotic Animal Formulary. 4th edn. Elsevier Saunders, USA. pp 564.
  • Mader D R (2006) Ed Reptile Medicine and Surgery. Saunders Elsevier, USA. pp 1242.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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