Exotis ISSN 2398-2985

Reptiles

Cefuroxime

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Cefuroxime axetil.
  • Cefuroxime sodium.

Class of drug

  • 2nd generation cephalosporin antibiotic.
  • Member of beta-lactam group (but resistant to some beta-lactamases).

Description

Chemical name

  • (6R,7R)-3-{[(aminocarbonyl)oxy]methyl}-7-{[(2Z)-2-(2-furyl)-2-(methoxyimino) acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.

Molecular formula

  • C16H15N4NaO8S.

Molecular weight

  • 446.4.

Physical properties

  • White or almost white, hygroscopic powder.
  • Insoluble in water and slightly soluble in dehydrated alcohol.

Storage requirements

  • Tablets: store at room temperature in tight containers. Protect from excessive moisture.
  • Powder for suspension: store at 2-30°C/35.6-86°F. Once reconstituted, it should be kept refrigerated (2-8°C/35.6-46.4°F) and any unused suspension discarded after 10 days.
  • Powder for injection:
    • Store at room temperature.
    • The powder may darken, but this does not indicate any loss of potency.
    • Reconstituted solutions are stable for 24 h at room temperature and 48 h refrigerated (if reconstituted at 90 mg/mL; if further diluted, the solution is stable under refrigeration for 7 days).

Uses

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Indications

  • Treatment of susceptible bacterial infections.
  • Not commonly indicated in reptile medicine.

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • Bacteriocidal activity reduced by concomitant use of bacteriostatic agents:
    • Tetracyclines.
    • Erythromycin.
  • Increased risk of nephrotoxicity if used with amphotericin or loop diuretics eg furosemide [Furosemide].
  • Reduced excretion if given with probenecid.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell, USA. pp 1296.
  • Carpenter J W & Marion C J (2013) Exotic Animal Formulary. 4th edn. Elsevier Saunders. USA. pp 564.
  • Girling S J & Raiti P (2004) BSAVA Manual of Reptiles. BSAVA, UK. pp 383.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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