Exotis ISSN 2398-2985

Reptiles

Ceftiofur

Synonym(s): Excede

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Ceftiofur.
  • Ceftiofur HCl.
  • Ceftiofur sodium
  • Ceftiofur crystalline free acid (ceftiofur HCl/sodium and ceftiofur crystalline free acid have significantly different characteristics).

Class of drug

  • 3rd generation parenterally administered beta-lactam antibacterial.

Description

Chemical name

  • (6R,7R)-7-[ [(2Z)-2-(2-Amino-1,3-thiazol-4-yl)- 2-methoxyiminoacetyl]amino]-3-(furan-2- carbonylsulfanylmethyl)-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.

Molecular formula

  • C19H17N5O7S3.

Molecular weight

  • Ceftiofur HCl: 560.
  • Ceftiofur crystalline free acid: 523.58.

Storage requirements

  • Ceftiofur crystalline free acid should be stored at controlled room temperature (20-25°C/68-77°F). Shake well before using.
  • Unreconstituted ceftiofur sodium powder should be stored at room temperature and protected from light. After reconstitution, it is stable for 7 days if refrigerated and 12 h at room temperature. It can be frozen for 8 weeks.

Uses

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Indications

  • Very effective for Devriesea agamarum infections.
  • Appropriate for other bacterial infections in reptiles, but ceftazidime may be superior for the most common pathogens isolated from reptiles.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • There may be an increased risk of nephrotoxicity when used in association with loop diuretics and aminoglycoside antimicrobials.
  • Bacteriostatic antimicrobials may reduce the efficacy of ceftiofur.
  • There may be reduced metabolism of phenylbutazone and phenytoin.
  • There may be reduced barbiturate metabolism and prolongation of phenobarbital anesthesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Rasmussen C, Allender M C, Phillips C A et al (2017) Multi-drug resistance patterns of enteric bacteria in two populations of free-ranging Eastern box turtles (Terrapene carolina carolina). J Zoo Wildl Med 48 (3), 708-715 VetMedResource.
  • Adkesson M J, Fernandez-Varon E, Cox S et al (2011) Pharmacokinetics of a long-acting ceftiofur formulation (ceftiofur crystalline free acid) in the ball python (Python regius). J Zoo Wildl Med 42 (3), 444-450 PubMed.
  • Hellebuyck T, Pasmans F, Haesebrouck F et al (2009) Designing a successful antimicrobial treatment against Devriesea agamarum infections in lizards. Vet Microbiol 139 (1-2), 189-192 PubMed.
  • Benson K G, Tell L A, Young L A et al (2003) Pharmacokinetics of ceftiofur sodium after intramuscular or subcutaneous administration in green iguanas (Iguana iguana). Am J Vet Res 64 (10), 1278-1282 PubMed.

Other sources of information

  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell, USA. pp 1296.
  • Bishop Y (2004) Ed The Veterinary Formlary. 6th edn. British Veterinary Association and Royal Pharmaceutical Society. ISBN: 0853695792.
  • Girling S J & Raiti P (2004) BSAVA Manual of Reptiles. BSAVA, UK. pp 383.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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