Exotis ISSN 2398-2985

Reptiles

Carprofen

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Carprofen.

Class of drug

  • Non-steroidal anti-inflammatory (NSAID).

Description

Chemical name

  • (RS)-2-(6-Chloro-9H-carbazol-2-yl)propanoic acid.

Molecular formula

  • C15H12ClNO2.

Molecular weight

  • 273.71.

Physical properties

  • White crystalline compound.
  • Practically insoluble in water and freely soluble in ethanol.

Storage requirements

  • Store injectable formulations in the fridge.
  • Once opened, it can be used for 28 days.
  • Oral formulations should be stored at room temperature.

Uses

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Indications

  • Pain control and reduction of inflammation.
  • Little use in reptile medicine due to the lack of studies reporting efficacy, safety and appropriate dosage.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Carprofen is highly protein-bound and may displace other protein-bound drugs, thereby increasing the risk of toxicity.
Nephrotoxic agents
  • Avoid the concurrent use of NSAIDs with other potentially nephrotoxic agents, eg aminoglycosides.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Trnkova S, Knotkova Z, Hrda A et al (2007) Effect of non-steroidal anti-inflammatory drugs on the blood profile in the green iguana (Iguana iguana). Veterinarni Medicina 52 (11), 507-511 VetMedResource.

Other sources of information

  • Meredith A (2015) Ed Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK.
  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell Publishing, USA. pp 1296.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.
  • McArthur S, Wilkinson R % Meyer J (2004) Medicine and Surgery of Tortoises and Turtles. Blackwell Publishing, UK. pp 579.
  • Girling S J & Raiti P (2004) BSAVA Manual of Reptiles. BSAVA, UK. pp 383.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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