Exotis ISSN 2398-2985

Reptiles

Buprenorphine

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Buprenorphine.

Class of drug

  • Long-acting partial opioid antagonist-agonist.

Description

Chemical name

  • (2-5R,6R,7R,14S)-9alpha-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylbutan-2-ol.

Molecular formula

  • C29H41NO4.

Molecular weight

  • 467.64.

Physical properties

  • White crystalline powder with solubility of 17 mg/mL in water and 42 mg/mL in alcohol.

Storage requirements

  • Buprenorphine should be stored at room temperature and protected from bright light.
  • Autoclaving may considerably decrease drug potency.

Uses

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Indications

  • Currently not indicated in reptiles, as studies have shown no analgesic effect.
  • Other analgesics have proved more effective in reptiles, eg morphine.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Opioid analgesics
  • Do not use in conjunction with these as it is a partial agonist and will antagonize the effects of full agonists (morphine, pethidine [Pethidine]).
  • May potentiate sedative and ventilatory depressant effects of other CNS depressants.
  • Can be used to reverse sedative effects of fentanyl/fluanisone while maintaining analgesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Mans C, Lahner L L, Baker B B et al (2012) Antinoceptive efficacy of buprenorphine and hydromorphone in red-eared slider turtles (Trachemys scripta elegans). J Zoo Wildl Med 43 (3), 662-665 PubMed.

Other sources of information

  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell, USA. pp 1296.
  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA, UK. ISBN: 9781905319657.
  • Carpenter J W & Marion C J (2013) Exotic Animal Formulary. 4th edn. Elsevier Saunders, USA. pp 564.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.
  • Mader D R (2006) Ed Reptile Medicine and Surgery. Saunders Elsevier, USA. pp 1242.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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