ISSN 2398-2985      

Xylazine

6guinea pig

Synonym(s): Xylazine HCl, Rompun, Virbaxyl, Sedazine, AnaSed, TranquiVed, Chanazine, Nerfasin, Sedaxylan, Xylacare, Xylapan


Introduction

Name

  • Xylazine.

Class of drug

  • Alpha-2 adrenoreceptor agonist.

Description

Chemical name

  • N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine.

Molecular formula

  • C12H16N2S.

Molecular weight

  • 220.33.

Storage requirements

  • Do not store over 30°C/86°F.

Uses

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Indications

  • Sedation.
  • Chemical restraint.
  • Pre-anesthetic medication.
  • In conjunction with other drugs to produce surgical anesthesia.
  • Largely superseded by medetomidine and dexmedetomidine:
    • Less specific for the α-2 adrenoceptor than are medetomidine and dexmedetomidine.
    • Not recommended any more when medetomidine or dexmedetomidine are available.

Administration

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Pharmacokinetics

Precautions

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Interactions

with diagnostic tests

  • Causes transient increase in blood glucose levels.
  • Suppresses ADH secretion.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.
  • Hawkins M G & Pascoe P J (2012) Anesthesia, Analgesia and Sedation of Small Mammals. In: Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery. 3rd edn. Eds: Quesenberry K E, Carpenter J W. Elsevier, USA. pp 429-451.
  • Maguire S & Hawk CT (2012) Formulary. In: The Laboratory Rabbit, Guinea Pig, Hamster and other Rodents. Eds: Suckow M, Stevens K & Wilson R. Academic Press, USA. pp 1193-1229.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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