ISSN 2398-2985      

Pentazocine

6guinea pig

Synonym(s): Pentazocine lactate, Pentazocine HCl, Talwin, Talacen, Pentazocine


Introduction

Name

  • Pentazocine.

Class of drug

  • Opioid analgesic.

Description

Chemical name

  • Pentazocine HCl: (2R*,6R*,11R*)-1,2,3,4,5,6-Hexahydro-6,11­ dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride.

Molecular formula

  • C19H27NO·HCl.

Molecular weight

  • 321.88.

Physical properties

  • Pentazocine HCl (oral): white, crystalline powder. Soluble in water and freely soluble in alcohol.
  • Pentazocine lactate (injectable): soluble in water.

Storage requirements

  • Room temperature and protected from light. The injection should not be frozen.

Uses

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Indications

  • Short-term management of mild to moderate pain.
  • It has little sedative effect, only a slight effect on the gastrointestinal (GI) tract and causes less respiratory depression than morphine Morphine.
Ineffective in management of severe pain.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Use with caution with other CNS or respiratory depressants.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Heard D J (1993) Principles and techniques of anesthesia and analgesia for exotic practitioners. Vet Clin North Am Small Anim Pract 23 (6), 1301-1327 PubMed.

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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