Exotis ISSN 2398-2985

Guinea Pigs

Glycopyrrolate

Synonym(s): Glycopyrrolate bromide, Glycopyrronium bromide, Robinul, Glycostigmin, Acpan, Gastrodyn

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Glycopyrrolate.

Class of drug

  • Antimuscarinic agent.

Description

Chemical name

  • 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide.

Molecular formula

  • C19H28BrNO3.

Molecular weight

  • 398.33.

Physical properties

  • Bitter tasting, practically odorless, white, crystalline powder.
  • •One gram is soluble in 20 mL of water and 30 mL of alcohol.

Storage requirements

  • Store at room temperature.

Uses

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Indications

  • Its use as a pre-anesthetic drug to reduce oral and bronchial secretions in no longer recommended in guinea pigs. Use only when there is an indication that excessive secretion may produce a problem.
  • In conjunction with long-acting anticholinesterase drugs, eg neostigmine, pyridostigmine during antagonism of neuromuscular block.
  • Pupil dilation in uveitis.
  • Treatment of bradycardia.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Alkaline drugs, eg barbiturates
  • When mixed a precipitate may form.
Antihistamines, benzodiazepines, prolonged corticosteroid use (may increase intraocular pressure), pethidine, phenothiazines, procainamide and quinidine
  • The adverse effects of antimuscarinics may be increased.
Nitrofurantoin, sympathomimetics and thiazide diuretics
  • Antimuscarinics may enhance the action.
Metoclopramide

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, United Kingdom. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Maguire S, Hawk CT (2012) Formulary. In: The Laboratory Rabbit, Guinea Pig, Hamster, and other Rodents. Eds: Suckow M, Stevens K, Wilson R. Academic Press, United States. pp 1193-1229.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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