Exotis ISSN 2398-2985

Guinea Pigs

Gabapentin

Synonym(s): Neurontin

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Gabapentin.

Class of drug

  • Analgesic and anti-epileptic drug (GABA[gamma-aminobutyric acid] agonist) - analog of GABA.

Description

Chemical name

  • 1-(aminomethyl) cyclohexaneacetic acid.

Molecular formula

  • C9H17NO2.

Molecular weight

  • 171.24.

Physical properties

  • White to off-white crystalline solid that is freely soluble in water.

Storage requirements

  • Store at room temperature.
  • Liquid form store in refrigerator.

Uses

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Indications

  • Adjunctive treatment of generalized seizures that are considered refractory to phenobarbitone and potassium bromide.
  • Adjunctive gabapentin therapy will reduce frequency of generalized seizures Seizures in over approximately 45% of idiopathic epileptic dogs refractory to phenobarbitone and potassium bromide therapy.
  • Adjunctive treatment of partial seizures Seizures with or without secondary generalization not satisfactorily controlled with other anti-epileptics.
  • Management of neuropathic. Studies in guinea pigs have demonstrated its efficacy to control this kind of pain.
  • Management of chronic pain.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • None confirmed with any other anti-convulsants but it may prolong half-life of felbamate by 50% when the two drugs are used together.
  • Oral clearance may decrease when given with cimetidine Cimetidine.

with diagnostic tests

  • Can give false positive urine protein tests (human data).
  • May also give rise to altered liver function tests in humans. Not known in guinea pigs.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Aghighi S A, Tipoid A, Piechotta M, Lewczuk P & Kastner S (2012) Assessment of the effects of adjunctive gabapentin on postoperative pain after intervertebral disc surgery in dogs. VAA 39, 636-646 PubMed.
  • Plessas I N, Rusbridge C, Driver C J, Chandler K E, Craig A, McGonnell I M, Brodbelt D C & Volk H A (2012) Long term outcome of Cavalier King Charles Spaniel dogs with clinical signs associated with Chiari-like malformation and syringomyelia. Vet Record 171, 501 PubMed.
  • Wagner A E, Mich P M, Uhrig S R & Hellyer P (2010) Clinical evaluation of perioperative administration of gabapentin as an adjunct for post-operative analgesia in dogs undergoing amputation of a forelimb. JAVMA 236,751-756 PubMed.
  • Pypendop B H, Siao K T & Ilkiw J E (2010) Thermal antinociceptive effect of orally administered gabapentin in healthy cats. Am J Vet Res 71, 1027-1032 PubMed.
  • Reid P, Pypendop B H & Ilkiw J E (2010) The effects of intravenous gabapentin administration on the minimum alveolar concentration of isoflurane in cats. Anaesth Analg 111, 633-637.
  • Cashmore R G, Harcourt-Brown T R, Freeman P M & Jeffery N D (2009) Clinical diagnosis and treatment of suspected neuropathic pain in three dogs. Aust Vet J 87, 45-50 PubMed.
  • Fox A, Gentry C, Patel S et al (2003) Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea pig. Pain 105 (1-2), 355-362 PubMed.
  • Hachad H, Ragueneau-Majlessi I & Levy R H (2002) New antiepileptic drugs: review on drug interactions. Therapeut Drug Monitoring. 24, 91-103. PubMed
  • Jensen A A, Mosbacher J, Elg S et al (2002) The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors. Molec Pharmacol. 61,1377-1384.PubMed
  • Radulovic L L, Turck D, Von Hodenberg A et al (1995) Disposition of gabapentin (neurontin) in mice, rats, dogs, and monkeys. Drug Metab Dispos. 23, 441-448 .PubMed

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, United Kingdom. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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