Exotis ISSN 2398-2985

Guinea Pigs

Fentanyl

Synonym(s): Fentanyl citrate, Carpujects, Sublimaze, Hypnorm (fentanyl-fluanisone), Actiq, Fenodia, Fenta-Hamelm, Fentanest, Sintenyl, Fentadon, Recuvyra, Durogesic, Fentora

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Fentanyl.

Class of drug

  • Synthetic opioid analgesic.

Description

Chemical name

  • N-Phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]propanamide.

Molecular formula

  • C22H28N2O.

Molecular weight

  • 336.47.

Physical properties

  • White, crystalline powder, sparingly soluble in water and soluble in alcohol.
  • Odorless and tasteless.

Storage requirements

  • Room temperature and protected from light.

Uses

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Indications

  • Analgesia for moderate to severe pain.
  • Sedation when combined with fluanisone.
  • In can be part of anesthetic protocols (fentanyl-midazolam-medetomidine, fentanyl-fluanisone-midazolam, generally followed by isoflurane for prolonged anesthesia).

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Pentobarbitone, narcotic analgesics and tranquilizers
  • May cause additive central nervous system or respiratory depression when given with fentanyl + fluanisone Pentobarbital.
Cimetidine
  • Cimetidine Cimetidine may cause increased plasma levels of fentanyl.

with diagnostic tests

  • Plasma amylase and lipase may be increased for up to 24 h following administration of fentanyl.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Schmitz S, Tacke S, Guth B et al (2016) Comparison of physiological parameters and anaesthesia specific observations during isoflurane, ketamine-xylazine or medetomidine-midazolam-fentanyl anaesthesia in male guinea pigs. PLOS ONE 11 (9), PubMed.

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, United Kingdom. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.
  • Hawkins M G, Pascoe P J (2012) Anesthesia, Analgesia and Sedation of Small Mammals. In: Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery. 3rd edn. Quesenberry K E. Ed: Carpenter J W. Elsevier, USA. pp 429-451.
  • Maguire S, Hawk C T (2012) Formulary. In: The Laboratory Rabbit, Guinea Pig, Hamster, and other Rodents. Eds: Suckow M, Stevens K, Wilson R. Academic Press, United States, pp 1193-1229.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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