ISSN 2398-2985      

Ephedrine

6guinea pig

Synonym(s): Ephedrine sulphate, Ephedrine hydrochloride, Enurace.


Introduction

Name

  • Ephedrine.

Class of drug

  • Sympathomimetic alkaloid.
  • Mixed alpha- and beta-adrenergic agonist, by causing the release of norepinephrine.

Description

Chemical name

  • (R*,S*)-2-(methylamino)-1-phenylpropan-1-ol.

Molecular formula

  • C10H15NO.

Molecular weight

  • 165.23 g.

Physical properties

  • Fine, odorless, white crystals or powder.
  • Approximately 770 mg are soluble in 1 mL of water.
  • Colorless aqueous solution.

Storage requirements

  • Room temperature.
  • Protect from light.

Uses

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Indications

  • Urinary incontinence (oral use).
  • Nasal congestion and bronchoconstriction (rarely used in guinea pigs for these conditions).
  • Treatment of hypotension during anesthesia.
  • Treatment of shock unresponsive to fluid replacement.

The administration of ephedrine is not a substitute for appropriate fluid resuscitation during shock.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Should not be used with other sympathomimetic agents or monoamine oxidase inhibitors.
  • Increased risk of hypertension if given with NSAIDs, tricyclic antidepressants.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Plumb D (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • Peck T E, Hill S A & Williams M (2005) Sympathomimetics. In: Pharmacology for Anaesthesia and Intensive Care. Greenwich Medical Media, UK. pp 187-208.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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