ISSN 2398-2985      

Dexamethasone

6guinea pig

Introduction

Name

  • Dexamethasone.

Class of drug

  • Corticosteroid.

Description

Chemical name

  • (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one.

Molecular formula

  • C22H29FO5.

Molecular weight

  • 392.46 g/mol.

Uses

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Indications

  • Anti-inflammatory potency 7.5x prednisolone.
  • Anti-inflammatory drug.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Amphotericin B or potassium-depleting diuretics (furosemide, thiazides)
  • Increased risk of hypokalemia with these drugs.
Insulin
  • May antagonize effects of insulin.
Phenobarbital or phenytoin
  • These drugs may accelerate the metabolism of glucocorticoids.
Non-steroidal inflammatory drugs
  • Increased risk of gastrointestinal ulceration if used concurrently.

with diagnostic tests

Urine glucose levels
  • May be increased.

Liver
  • Elevated liver enzymes.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets.  9th edn. BSAVA, UK.
  • Carpenter J W & Marion C J (2013) Exotic Animal Formulary. 4th edn. Saunders, USA.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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