Exotis ISSN 2398-2985

Guinea Pigs

Cimetidine

Synonym(s): Cimetidine hydrochloride, Tagamet, Zitac, Dyspamet

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Cimetidine.

Class of drug

  • Histamine H2 receptor-antagonist.

Description

Chemical name

  • N-cyano-N'-methyl-N"-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine.

Molecular formula

  • C10H16N6S.

Molecular weight

  • 288.80.

Physical properties

  • White to off-white crystalline powder.
  • Unpleasant odor and bitter taste.
  • Sparingly soluble in water, soluble in alcohol.
  • Cimetidine HCl is very soluble in water and soluble in alcohol.

Storage requirements

  • Room temperature and protected from light.
  • Injectable product should not be refrigerated as precipitation may occur.

Uses

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Indications

  • Gastric and duodenal ulcers.
  • Uremic gastritis.
  • Stress or drug-related erosive gastritis.
  • Esophagitis.
  • Hypersecretory conditions secondary to gastrinoma or mastocytosis.
  • May be useful as an immunomodulating agent by preventing activation of suppressor T-cells by histamine.

Administration

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Pharmacokinetics

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Precautions

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Interactions

  • Newer H2 blockers such as ranitidine or famotidine have fewer drug interactions, have longer duration of activity and may be more effective.

with other drugs

Drugs affected by cimetidine (increased plasma levels)
  • Beta-blockers, eg propranolol.
  • Calcium channel blockers, eg verapamil.
  • Diazepam Diazepam.
  • Lignocaine Lidocaine.
  • Metronidazol.
  • Pethidine.
  • Phenytoin.
  • Quinidine.
  • Theophylline.
  • Warfarin.
  • Phenobarbital.
Sucralfate
  • Sucralfate may reduce bioavailability of H2 antagonists.
  • Whilst there is little evidence to suggest that this is clinically significant it may be wise to administer sucralfate at least with 2 h of difference from cimetidine.
Antacids, digoxin, ketoconazole, metoclopropamide
  • Stagger oral doses of cimetidine when used with these drugs Metoclopramide by 2 h.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Meredith A (2015) Ed Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, Quedgeley, Gloucester, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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