ISSN 2398-2985      

Butorphanol

6guinea pig

Introduction

Name

  • Butorphanol.

Class of drug

  • Opioid analgesic.
  • Antitussive.
  • Anti-emetic (not significant in guinea pigs).

Description

Chemical name

  • (4bR,8aR,9S)-11-(cyclobutylmethyl)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-3,8a-diol.

Molecular formula

  • C21H29NO2.

Molecular weight

  • 327.47.

Storage requirements

  • Protect from light.

Uses

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Indications

  • Antitussive/analgesic.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • The depressant activity of butorphanol may be potentiated by barbiturate anesthetics, phenothiazines and tranquilizers.
  • Concomitant use with metoclopramide Metoclopramide may lead to antagonism as each drug has opposing effects on gastrointestinal motility. In practice this is probably of little clinical significance.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A & Lord B (2014) Eds. BSAVA Manual of Rabbit Medicine. BSAVA. ISBN: 9781905319497.
  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA. ISBN: 9781905319657.
  • Varga M (2013) Textbook of Rabbit Medicine. 2nd edn. Elsevier. ISBN: 9780702049798.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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