Exotis ISSN 2398-2985

Ferrets

Blood biochemistry: gammaglutamyl transferase

Synonym(s): GGT, Gammaglutamyl transpeptidase, ⍺-Glutaryltransferase

Contributor(s): Vetstream Ltd, David Perpinan

Overview

  • Gammaglutamyl transferase (GGT) is a membrane-associated enzyme, produced in liver, pancreas and kidney.
  • Liver GGT is found primarily in the epithelium of the bile ducts.
  • The hepatobiliary system is therefore the primary source of serum GGT and is more diagnostic for hepatobiliary disease than for hepatocellular damage.
  • In addition to biliary GGT, which is the main source of GGT, significant levels of renal epithelial GGT can be found in the urine.
  • Urine GGT levels may be increased in cases of renal damage; in addition, plasma GGT may also be increased in these cases, but this is rare.

Sampling

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Tests

Methodologies

  • Varies between laboratories, usually colorimetric method based on enzymatic reaction.

Availability

  • Widely available.

Validity

Predictive value

Technique (intrinsic) limitations

  • Test results most significant in conjunction with other laboratory results and clinical findings.

Result Data

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Hein J, Spreyer F, Sauter-Louis C et al (2012) Reference ranges for laboratory parameters in ferrets. Vet Rec 171, 218 PubMed.
  • Hauptman K, Tichy F & Znotek Z (2001) Clinical diagnostics of hepatopathies in small mammals: evaluation of importance of individual methods. Acta Vet Brno 70, 297-311.

Other sources of information

  • Phelps C A & Mayer J (2013) Gammaglutamyl Transferase. In: Clinical Veterinary Advisor Birds and Exotic Pets. Eds: Mayer J & Donnelly T M. Eslevier, St Louis. pp 617-618.


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