ISSN 2398-2985      

Blood biochemistry: alanine aminotransferase

4ferrets

Synonym(s): SGPT, ALT


Overview

  • Released to serum after damage to, or proliferation of, hepatocytes.
  • Heart muscle may have similar ALT activity to liver, although not properly reported in ferrets.
  • Low concentrations of ALT in erythrocytes and skeletal muscle may cause minor ALT increases in hemolytic diseases, muscle wasting, or muscle injury.
  • Elevations, some of them significant and over 1000 IU/L, are commonly seen in ferrets with hepatic disease.

Sampling

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Tests

Methodologies

  • Varies between laboratories.

Availability

  • Widely available.

Validity

Sensitivity

  • May be good in ferrets for liver disease.

Specificity

  • ALT is highly liver specific in the ferret.

Predictive value

  • Amount and duration of increase is indicative of severity and chronicity of problem.

Result Data

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Li T, Yoshizaki S, Kataoka M et al (2017) Genetic and physicochemical analyses of a novel ferret hepatitis E virus, and clinical signs of infection after birth. Infection Genetics and Evolution 51, 153-159 PubMed.
  • Vilalta L, Espada Y, Majó N et al (2016) Liver lobe torsion in a domestic ferret (Mustela putorius furo). J Exotic Pet Med 25 (4), 321-326 VetMedResource.
  • Hein J, Spreyer F, Sauter-Louis C et al (2012) Reference ranges for laboratory parameters in ferrets. Vet Rec 171, 218 PubMed.
  • Hall B A & Ketz-Riley C J (2011) Cholestasis and cholelithiasis in a domestic ferret (Mustela putorius furo). J Vet Diag Invest 23 (4), 836-839 PubMed.
  • Hauptman K, Tichy F & Znotek Z (2001) Clinical diagnostics of hepatopathies in small mammals: evaluation of importance of individual methods. Acta Vet Brno 70, 297-311.

Other sources of information

  • Fox J G & Marini R P (2014) Eds. Biology and Diseases of the Ferret. 3rd edn. Wiley Blackwell, USA. pp 835.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Fudge A M (1999) Laboratory Medicine. Avian and Exotic Pets. W B Saunders Co. ISBN: 0721 676 790.

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