Exotis ISSN 2398-2985

Ferrets

Theophylline

Synonym(s): Corvental

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Theophylline.

Class of drug

  • Methylxanthine.
  • Bronchodilator.

Description

Chemical name

  • 1,3-dimethyl-7H-purine-2,6-dione.

Molecular formula

  • C7H8N4O2.

Molecular weight

  • 180.16.

Physical properties

  • White, odorless, bitter-taste crystalline powder.

Storage requirements

  • Store in a dry place and below 30°C/86°F.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

  • Useful as a bronchodilator in the management of several pulmonary conditions (eg pulmonary edema secondary to congestive heart failure), emphysema, bronchitis.

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmacokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

Macrolide and fluoroquinolone antibiotics
  • Plasma theophylline levels may be increased.
Phenobarbital
  • May decrease theophylline's effect.
Cimetidine
  • Plasma theophylline levels may be increased.
Diltiazem
  • Plasma theophylline levels may be increased.
Verapamil
  • Plasma theophylline levels may be increased.
Pancuronium
  • Theophylline may decrease the effects.
Phenytoin
  • Theophylline may decrease the effects.
Beta-adrenergic blockers, eg propranolol
  • May antagonize each other.
Anesthetics
  • There is an increased risk of dysrhythmias if theophylline is administered with halothane.
  • There is an increased incidence of seizures with ketamine.
  • Hyperesthesia seen in cats.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • Johnson-Delaney C A (2017) Ferret Medicine and Surgery. CRC Press, USA. pp 514.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, Cheltenham, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

ADDED