ISSN 2398-2985      

Theophylline

4ferrets

Synonym(s): Corvental


Introduction

Name

  • Theophylline.

Class of drug

  • Methylxanthine.
  • Bronchodilator.

Description

Chemical name

  • 1,3-dimethyl-7H-purine-2,6-dione.

Molecular formula

  • C7H8N4O2.

Molecular weight

  • 180.16.

Physical properties

  • White, odorless, bitter-taste crystalline powder.

Storage requirements

  • Store in a dry place and below 30°C/86°F.

Uses

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Indications

  • Useful as a bronchodilator in the management of several pulmonary conditions (eg pulmonary edema secondary to congestive heart failure), emphysema, bronchitis.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Macrolide and fluoroquinolone antibiotics
  • Plasma theophylline levels may be increased.
Phenobarbital
  • May decrease theophylline's effect.
Cimetidine
  • Plasma theophylline levels may be increased.
Diltiazem
  • Plasma theophylline levels may be increased.
Verapamil
  • Plasma theophylline levels may be increased.
Pancuronium
  • Theophylline may decrease the effects.
Phenytoin
  • Theophylline may decrease the effects.
Beta-adrenergic blockers, eg propranolol
  • May antagonize each other.
Anesthetics
  • There is an increased risk of dysrhythmias if theophylline is administered with halothane.
  • There is an increased incidence of seizures with ketamine.
  • Hyperesthesia seen in cats.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Johnson-Delaney C A (2017) Ferret Medicine and Surgery. CRC Press, USA. pp 514.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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