ISSN 2398-2985      

Sucralfate

4ferrets

Synonym(s): Antepsin, Carafate


Introduction

Name

  • Sucralfate.

Class of drug

  • Mucosal protectant.
  • Ulcer-healing agent.

Description

Chemical name

  • [({[(2S,3R,4S,5R,6R)-4,5-bis({[(dihydroxyalumanyl)oxy]sulfonyl}oxy)-6-[({[(dihydroxyalumanyl)oxy]sulfonyl}oxy)methyl]-2-{[(2R,3S,4S,5R)-3,4,5-tris({[(dihydroxyalumanyl)oxy]sulfonyl}oxy)-2-[({[(dihydroxyalumanyl)oxy]sulfonyl}oxy)methyl]oxolan-2-yl]oxy}oxan-3-yl]oxy}sulfonyl)oxy]alumanediol.

Molecular formula

  • C11H44Al8O51S8.

Molecular weight

  • 1464.75.

Physical properties

  • White, amorphous powder.
  • Practically insoluble in water and alcohol. ​

Storage requirements

  • Store in tight containers at room temperature.

Uses

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Indications

  • Esophageal, gastric and duodenal ulceration, usually with H2 antagonist, eg cimetidine, ranitidine, but given separately.
  • It can be included in protocols to treat infection by Helicobacter mustelae.
  • It could potentially be used to treat hyperphosphatemia.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Sucralfate may impair the oral absorption of the following drugs (separate doses by at least 2 h to minimize this effect):
    • Ciprofloxacin.
    • Digoxin.
    • Ketoconazole.
    • Levothyroxine.
    • Penicillamine.
    • Tetracyclines.
    • Vitamins (fat soluble).
    • Warfarin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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