ISSN 2398-2985      

Phenoxybenzamine

4ferrets

Synonym(s): Dibenzyline


Introduction

Name

  • Phenoxybenzamine.

Class of drug

  • Non-selective alpha-adrenergic receptor antagonist.

Description

Chemical name

  • N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine.

Molecular formula

  • C18H22ClNO.

Molecular weight

  • 303.83.

Physical properties

  • Odorless, white crystallien powder.
  • 40 mg are soluble in 1 mL of water and 167 mg are soluble in 1 mL of alcohol.

Storage requirements

  • Store at room temperature in well-closed containers.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

  • Used to reduce internal urethral tone (urinary obstruction, after urethral surgery, etc).
  • Severe hypertension in animals with pheochromocytoma prior to surgery (in conjunction with a beta-blocker).

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Pharmacokinetics

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

with other drugs

Beta-blockers and diuretics
  • There is an increased risk of a first-dose hypotensive effect with beta-blockers and diuretics.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!