ISSN 2398-2985      

Pentoxifylline

4ferrets

Introduction

Name

  • Pentoxifylline.

Class of drug

  • Hemorrheologic.
  • Immunomodulatory agent.
  • Methylxanthine derivative.

Description

Chemical name

  • 3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione.

Molecular formula

  • C13H18N4O3.

Molecular weight

  • 278.31.

Physical properties

  • White, odorless, bitter-tasting, crystalline powder.
  • At room temperature, 77 mg are soluble in 1 mL of water and 63 mg are soluble in 1 mL of alcohol.

Storage requirements

  • Store at room temperature, in well-closed containers and protected from light.

Uses

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Indications

  • Vasculitis: its use has been suggested to treat vasculitis associated with ferret systemic coronavirus disease.
  • Any condition where improved microcirculation may be of benefit (damage to distal part of appendages, etc).

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Antihypertensive drugs
  • Pentoxifylline may potentiate hypotensive effects.
Platelet-aggregation inhibitors, eg aspirin, and warfarin
  • Increased risk for bleeding.
Theophylline
  • Serum levels may be increased when used with pentoxifylline.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Johnson-Delaney C A (2017) Ferret Medicine and Surgery. CRC Press, USA. pp 514.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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