Exotis ISSN 2398-2985

Ferrets

Naloxone

Synonym(s): Narcan, Naloxone

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Naloxone.

Class of drug

  • Opioid antagonist (pure antagonist, no agonist properties at all).

Description

Chemical name

  • (1S,5R,13R,17S)-10,17-dihydroxy-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one.

Molecular formula

  • C19H21NO4.

Molecular weight

  • 327.37.

Physical properties

  • White to slightly off-white powder.
  • Soluble in water and slightly soluble in alcohol.

Storage requirements

  • Room temperature and protected from light.

Uses

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Indications

  • Indicated for treatment of gross overdosage of all narcotic including agonist/antagonists, eg butorphanol, nalbuphine.
  • Has been used in the management of shock (high doses).
  • To identify persistent opioid activity (a small IV dose will give transient increase in consciousness when persistent opioid activity contributes to prolonged anesthetic recovery).
  • To reverse anesthesia with opioids.

Administration

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Precautions

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Interactions

with other drugs

Narcotics
  • The narcotic effects may persist longer than that of naloxone, therefore monitor animals being treated for overdose carefully, until the narcotic effects remain negated. Doses of naloxone may need to be repeated.
  • Naloxone will also reverse the analgesic effects of narcotics.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, United Kingdom. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA. ISBN: 9781905319657.
  • Veterinary Medicines Directorate (2013) Veterinary Medicines Guidance Notes. Website: www.gov.uk.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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