ISSN 2398-2985      

Moxidectin

4ferrets

Synonym(s): Advocate, Cydectin, Pro-Heart, Quest


Introduction

Name

  • Moxidectin.

Class of drug

  • Avermectin-class antiparasitic.
  • Macrocyclic lactone.
  • 16 member pentacyclic lactone of the milbemycin class.
  • Semi-synthetic milbemycin.
  • Derived from the actinomycete Streptomycetes cyaneogriseus noncyanogenus.

Description

Chemical name

  • (6R,23E,25S)-5-O-demethyl-28-deoxy-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino) milbemycin B.
  • 23-(O-Methyloxime)-F28249-a.

Molecular formula

  • C37H53NO8.

Molecular weight

  • 639.84 g.

Physical properties

  • White to pale yellow crystalline powder.
  • Differ from avermectins in the abscence of a disaccharide chain at C13.
  • Melting point: 145-154°C/293-309.2°F.
  • Solubility in water: 0.51 mg/l.
  • Readily soluble in organic solvents.

Storage requirements

  • Tablets: room temperature and protected from light.
  • Topical: at or below room temperature.
  • Injectable: store the unconstituted product at or below room temperature and protected from light. After constitution, the product is stable for 8 weeks in the refrigerator.

Uses

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Indications

  • For the treatment of ectoparasites and nematodes: fleas, ear mites, heartworm.
  • No action against trematodes, protozoa or cestodes.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • No other antiparasitic marcocyclic lactone should be administered concurrently.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Wenzel U, Heine J, Mengel H et al (2008) Efficacy of imidacloprid 10%/moxidectin 1% (Advocate (R)/Advantage Multi (TM)) against fleas (Ctenocephalides felis felis) on ferrets (Mustela putorius furo). Parasitol Res 103 (1), 231-234 PubMed.

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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