Exotis ISSN 2398-2985

Ferrets

Metoclopramide

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Metoclopramide.

Class of drug

  • Gastrointestinal prokinetic agent.
  • Upper gastrointestinal tract stimulant.

Description

Chemical name

  • 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide.

Molecular formula

  • C14H22CIN3O2.

Molecular weight

  • 299.79.

Physical properties

  • Odorless, white, crystalline powder.
  • One gram is soluble in 0.7 mL of water and 3 mL of alcohol.

Storage requirements

  • Store in light-resistant containers at room temperature.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

  • Acts as an upper gastrointestinal stimulant with antiemetic properties.
  • Prevention of emesis in cases of chemotherapy.
  • Prevention of gastroesophageal reflux and enhancer of gastroesophageal motility in cases of megaesophagus.
  • Its use to prevent vomiting in gastritis is questionable.

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmacokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

Antimuscarinic drugs, eg atropine, and narcotic analgesics
  • The activity of metoclopropamide may be inhibited.
Narcotics, sedatives or tranquilizers
  • The central nervous system (CNS) effects of metoclopramide may be enhanced.
Tetracyclines, cyclosporine
  • Metoclopramide increase the rate and extent of GI absorption.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Quesenberry K E, Carpenter J W (2004) Formulary. In: Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery. 2nd ed. pp 436-444.

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, United Kingdom. pp 195.
  • Plumb D (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

ADDED