ISSN 2398-2985      

Meloxicam

4ferrets

Synonym(s): Metacam, Mobi, Mobicox


Introduction

Name

  • Meloxicam.

Class of drug

  • Non-steroidal anti-inflammatory drug (NSAID).

Description

Chemical name

  • 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1$l^{6},2-benzothiazine-3-carboxamide.

Molecular formula

  • C14H13N3O4S2.

Molecular weight

  • 351.39

Physical properties

  • Pale yellow powder.
  • Practically insoluble in water, with higher solubility observed in strong acids and bases.

Storage requirements

  • Store at room temperature.

Uses

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Indications

  • Alleviate mild to moderate musculoskeletal pain and inflammation.
Analgesic action is enhanced if adminstered pre-emptively.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Fluoroquinolones
  • Increase risk of convulsions (in man).
Anti-hypertensives, eg beta-blockers
  • Hypotensive effects may be antagonized.
Diuretics, aminoglycosides
  • May increase risk of nephrotoxicity.
Aspirin, corticosteroids, warfarin, other NSAIDs
  • Increased risk of bleeding.
Digoxin
  • NSAIDs may increase serum levels.

with diagnostic tests

  • May cause false low values for T3 and T4.

Adverse Reactions

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Further Reading

Publications

Publications

  • Recent references from PubMed and VetMedResource.
  • Chinnadurai D K, Messenger K M, Papich M G et al (2014) Meloxicam pharmacokinetics using nonlinear mixed-effects modeling in ferrets after single subcutaneous administration. J Vet Pharmacol Therap 37 (4), 382-387 PubMed.

Other sources of information

  • Meredith A (2015) Ed. BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 195.
  • Plumb D (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • Quesenberry K E & Carpenter J W (2012) Formulary. In: Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery, 3rd edn. pp 566-575.
  • Tennant Bryn (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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