ISSN 2398-2985      

Melatonin

4ferrets

Synonym(s): Regulin, Ferretonin, Benedorm, Melatol


Introduction

Name

  • Melatonin.

Class of drug

  • Pineal gland hormone.
  • Biogenic amine.

Description

Chemical name

  • N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide.

Molecular formula

  • C13H16N2O2.

Molecular weight

  • 232.28.

Physical properties

  • White/cream to yellowish crystalline powder.

Storage requirements

  • Store at room temperature in tight containers.

Uses

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Indications

  • Palliative treatment for adrenal disease.
  • Its use is of questionable utility; while it improves clinical signs, it masks the development of the disease.
  • Can be used with other treatments such as leuprolide Leuprolide acetate, anastrozole Anastrazole, bicalutamide, finasteride Finasteride.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Melatonin may potentiate effects of benzodiazepines and succinylcholine.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Ramer J C, Benson K G, Morrisey J K et al (2006) Effects of melatonin administration on the clinical course of adrenocortical disease in domestic ferrets. J Am Vet Med Assoc 229 (11), 1743-1748 PubMed.
  • Murray J (2005) Melatonin implants: an option for use in the treatment of adrenal disease in ferrets. Exot Mam Med Surg (1), 1-6 VetMedResource.

​Other sources of information

  • Plumb D (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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