Exotis ISSN 2398-2985

Ferrets

Loperamide

Synonym(s): Loperamide hydrochloride, Diareze, Imodium, Norimode

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Loperamide.

Class of drug

  • Opiate (derivative) antidiarrheal.

Description

Chemical name

  • 4-(4-chlorophyenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutanamide.
  • 4-(p-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutyramide.

Molecular formula

  • C29H33ClN2O2.

Molecular weight

  • 477.03.

Physical properties

  • White to faintly yellow powder.
  • Soluble in alcohol and slightly soluble in water.

Storage requirements

  • Store at room temperature in well-closed containers.

Uses

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Indications

  • Non-specific acute and chronic diarrhea.
  • Irritable bowel syndrome.
  • Emetic when given SC.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Do not give with ketoconazole or itraconazole.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, United Kingdom. pp 338.
  • Plumb D (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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