Exotis ISSN 2398-2985

Ferrets

Ivermectin

Synonym(s): Heartgard, Ivomec, Xeno

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Ivermectin.

Description

Chemical name

  • Ivermectin is a mixture containing at least 90% 5-O­ demethyl-22,23-dihydroavermectin A1a and less than 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­ 25-(1-methylethyl)avermectin A1a.

Molecular formula

  • C48H74O14.

Molecular weight

  • 875.

Physical properties

  • Off-white to yellowish powder.
  • Very poorly soluble in water, but soluble in propylene glycol and vegetable oils.

Storage requirements

  • Store at room temperature and protected from light.
  • Ivermectin 1% oral solution is stable at 1:20 and 1:40 dilutions with water for 72 h when stored in a tight container, at room temperature, and protected from light.

Uses

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Indications

  • Management of ectoparasitic and endoparasitic infestations.
  • Not effective for cestodes.

Administration

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Pharmacokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed BSAVA Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, United Kingdom. pp 338.
  • Fox J G & Marini R P (2014) Eds Biology and Diseases of the Ferret. 3rd edn. Wiley Blackwell, USA. pp 835.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, Iowa, USA. pp 1120.
  • Quesenberry K E & Carpenter J W (2004) Formulary. In: Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery. 2nd edn. pp 436-444.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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