ISSN 2398-2985      

Itraconazole

4ferrets

Synonym(s): Sporanox, Itrafungol


Introduction

Name

  • Itraconazole.

Class of drug

  • Triazol antifungal.

Description

Chemical name

  • (±)-1-[(RS)-sec-butyl]-4-[p-[4-[p-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4­ triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-∆2­ 1,2,4-riazolin-5-one.

Molecular formula

  • C35H38Cl2N8O4.

Molecular weight

  • 706.

Physical properties

  • White to slightly yellowish powder.
  • It is insoluble in water, very slightly soluble in alcohols, and freely soluble in dichloromethane.
  • Avoid compounding if possible.

Storage requirements

  • Store capsules at room temperature protected from light and moisture.
  • Oral solution should be stored at temperatures <26°C/78.8°F.
  • Avoid freezing.

Uses

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Indications

  • Aspergillosis, candidiasis , blastomycosis, coccidiomycosis , cryptococcosis, histoplasmosis and dermatophytoses.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Antacids, H2 antagonists and adsorbents
  • Antacids, H2 antagonists and adsorbents may reduce the absorption of itraconazole.
  • Itraconazole may inhibit metabolism of many drugs such as antihistamines, oral hypoglycemics, antiepileptics, cisapride, corticosteroids, cyclophosphamide, cyclosporin, ivermectin, digoxin and fentanyl, potentiating toxic effects.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, Quedgeley, UK. pp 338.
  • Fox J G & Marini R P (2014) Eds. Biology and Diseases of the Ferret. 3rd edn. Wiley Blackwell, USA. pp 835.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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