ISSN 2398-2985      

Isoflurane

4ferrets

Introduction

Name

  • Isoflurane.

Class of drug

  • Inhalational anesthetic.

Description

Chemical name

  • 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane.
  • 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether.

Molecular formula

  • C3H2ClF5O.

Molecular weight

  • 184.49 g/mol.

Physical properties

  • Volatile halogenated ether.
  • Structural isomer of enflurane.
  • Colorless, stable liquid.
  • Pungent ethereal odor.
  • Non-flammable.
  • Non-explosive.

Storage requirements

  • Store at room temperature.
  • Store away from direct heat and sunlight.
  • In original tight container.

Uses

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Indications

  • An inhalational anesthetic.
  • Maintenance of anesthesia for all types of surgery, irrespective of age.

Rapid recovery following painful, eg orthopedic procedures, necessitates appropriate and rapid attention to analgesia (isoflurane does not have analgesic properties).

  • Assertations that isoflurane is safer than halothane in certain high risk cases should be discounted.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Duration of non-depolarizing neuromuscular blocking agents is longer in isoflurane, compared with halothane-anesthetized animals.
  • Opioid agonists, benzodiazepines and nitrous oxide reduce the concentration of isoflurane required to achieve surgical anesthesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Lawson A K, Lichtenberger M, Day T et al (2006) Comparison of sevoflurane and isoflurane in domestic ferrets (Mustela putorius furo). Vet Ther (3), 207-212 PubMed.

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 338.
  • Ramsey I et al (2011) Isoflurane. In: BSAVA Small Animal Formulary. 7th edn. BSAVA, UK.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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