Exotis ISSN 2398-2985

Ferrets

Hydromorphone

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Hydromorphone hydrochloride.

Class of drug

  • Scheduled Class II opioid (narcotic).
  • Controlled substance.

Description

Molecular formula

  • 4,5±-epoxy-3-hydroxy-17-methylmorphinan-6-one hydrochloride.

Molecular weight

  • 321.80.

Physical properties

  • White powder.
  • Freely soluble in water.
  • Semi-synthetic phenanthrene alkaloid of opium.

Storage requirements

  • Store at room temperature (15-30°C/59-86°F).
  • Protect from light.
  • A slight yellowish tint to the solution may occur, but does not indicate loss of potency.
  • The injection remains stable for at least 24 h when mixed with commonly used IV fluids if protected from light.

Uses

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Indications

  • Use as an opioid analgesic.
  • A cost-effective alternative to oxymorphone.
  • Can be used pre-emptively for elective surgical procedures.
  • Can be used to relieve pain from trauma.
  • Has also been used to provide longer-term pain relief, eg that caused by osteosarcoma.
  • Hydromorphone is more effective at relieving continuous, dull pain versus sharp, intermittent pain.
  • Cough supressant at low doses.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Can cause profound sedation when combined with acepromazine, alpha2-agonists (xylazine, medetomidine) and benzodiazepines.
  • Hydromorphone may reduce the induction dose of injectable anesthetic agents and lower the dose of inhalant agents required for maintenance of anesthesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Myers D & Jung R A (2009) Hydromorphone. J Exotic Pet Med 18 (1), 71-73.

Other sources of information

  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, Iowa, USA. pp 1120.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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