ISSN 2398-2985      

Famotidine

4ferrets

Synonym(s): Pepcid


Introduction

Name

  • Famotidine.

Class of drug

  • H2 receptor antagonist.

Description

Chemical name

  • 3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]-N'-sulfamoylpropanimidamide.

Molecular formula

  • C8H15N7O2S3.

Molecular weight

  • 337.43.

Physical properties

  • White to pale yellow crystalline powder.
  • It is odorless, but has a bitter taste.
  • 740 µg are soluble in one mL of water.

Storage requirements

  • Tablets should be stored in well-closed, light-resistant containers at room temperature.
  • The powder for oral suspension should be stored in tight containers at temperatures <40°C/104°F:
    • After reconstitution, the resultant suspension is stable for 30 days when stored at temperatures less than 30°C/86°F.
    • Do not freeze.
  • Injection should be stored in the refrigerator.

Uses

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Indications

  • Treatment of gastroduodenal ulceration and gastritis.
  • Severe reflux esophagitis, eg megaesophagus, gastric foreign bodies.

Administration

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Pharmacokinetics

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Precautions

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Interactions

  • Fewer drug interaction than cimetidine.
  • By raising the pH of the stomach, famotidine may decrease the absorption of azole antifungals, some cephalosporins and oral iron.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, Quedgeley, UK. pp 338.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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