ISSN 2398-2985      

Etomidate

4ferrets

Synonym(s): Amidate, Hypnomidate, Radenarcon, Sibul


Introduction

Name

  • Etomidate.

Class of drug

  • Potent, short-acting, injectable anesthetic.
  • Carboxylic imidazole anesthetic.
  • Non-barbiturate.

Description

Chemical name

  • ethyl 3-[(1R)-1-phenylethyl]imidazole-4-carboxylate.

Molecular formula

  • C14H16N2O2.

Molecular weight

  • 244.29.

Physical properties

  • White or almost white powder.
  • Very slightly soluble in water and freely soluble in alcohol.
  • Commercially available as a hyperosmolar solution. ​

Storage requirements

  • Store at room temperature and protected from light.

Uses

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Indications

  • Anesthetic induction, particularly in ferrets with preexisting cardiac dysfunction, head trauma, or that are critically ill.
  • Etomidate at usual doses is sufficient for intubation.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Additive depression of the CNS or respiratory function is seen when combined with barbiturates, opiates, anesthetics and other CNS/respiratory depressants.
  • Verapamil potentiates the anesthetic and respiratory depressant effects of etomidate.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Johnson-Delaney C A (2017) Ferret Medicine and Surgery. CRC Press, USA. pp 514.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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