ISSN 2398-2985      

Enrofloxacin

4ferrets

Introduction

Name

  • Enrofloxacin.

Class of drug

  • Fluoroquinolone antibiotic.

Description

Chemical name

  • 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxoquinoline-3-carboxylic acid.

Molecular formula

  • C19H22FN3O3.

Molecular weight

  • 359.40.

Physical properties

  • Pale yellow, crystalline powder.
  • Slightly soluble in water. ​

Storage requirements

  • Tablets should be stored in tight containers at temperature less than 30°C/86°F.
  • Protect from direct sunlight.
  • Injectable forms should be kep at room temperature and should not be refrigerated or frozen. ​

Uses

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Indications

  • Used to treat bacterial infections.
  • Good activity against many gram negative bacilli and cocci, and some gram positive bacteria such as Staphylococcus.
  • Good activity against Chlamydia, Rickettsia, Mycoplasma and Mycobacterium.
  • Low activity against Streptococcus.
  • Ineffective to treat anaerobic infections.
  • Resistance seen in Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter and enterococci.
  • The fluoroquinolones are highly lipophilic drugs which attain high concentrations within the cells of many tissues and are particularly effective in the management of soft tissue, urogenital (including prostatic) and skin infections.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Adsorbents and antacids containing cations (Mg, Al)
  • May bind to enrofloxacin and prevent its absorption.
Sucralfate and zinc salts
Probenecid/cisapride
  • Blocks the tubular secretion of enrofloxacin and may increase its blood level and half-life.
NSAIDs
  • In man concurrent use of enrofloxacin and NSAIDs potentiates adverse CNS effects in epileptic patients.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Mentre V & Bulliot C (2015) A retrospective study of 17 cases of mycobacteriosis in domestic ferrets (Mustela putorius furo) between 2005 and 2013. J Exotic Pet Med 24 (3), 340-349 ExoticPetMed.
  • Nakata M, Miwa Y, Tsuboi M et al (2014) Mycobacteriosis in a Domestic Ferret (Mustela putorius furo). J Vet Med Sci 76 (5), 705-709 PubMed.​

Other sources of information

  • Meredith A (2015) Ed Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, Quedgeley, UK. pp 338.
  • Fox J G & Marini R P (2014) Biology and Diseases of the Ferret. 3rd edn. Wiley Blackwell, USA. pp 835.
  • Ramsey I (2014) BSAVA Small Animal Formulary. 8th edn. BSAVA, UK. ISBN: 9781905319657.
  • Keeble E & Meredith A (2009) BSAVA Manual of Rodents and Ferrets. BSAVA, UK.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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